Nijmegen periodic fever research group

Hyper-IgD and periodic fever syndrome (HIDS)

Research activities

Scientific achievements and events in the area of hereditary autoinflammatory syndromes and periodic fever in general—by (members of) the Nijmegen periodic fever research group, arranged chronologically.

                                       Last update: February 11, 2006

Publications

> van der Hilst JCH, Drenth JPH, Bodar EJ, Bijzet J, van der Meer JWM, Simon A and contributing members of the International HIDS Study Group.  Serum amyloid A serum concentrations and genotype do not explain low incidence of amyloidosis in Hyper-IgD syndrome. Amyloid 2005;12:115-119. PDF-file.

> Bodar EJ, Van der Hilst JCH, Drenth JPH, Van der Meer JWM, Simon A. Effect of etanercept and anakinra on inflammatory attacks in the Hyper-IgD syndrome: introducing a vaccination provocation model. Neth J Med 2005; 63:260-4. PDF-file.

> De Koning HD, Bodar EJ, Simon A, Van der Hilst JCH, Netea MG, Van der Meer JWM. Beneficial response to anakinra and thalidomide in Schnitzler’s syndrome. Ann Rheum Dis, published online 11 aug 2005; doi:10.1136/ard.2005.045245. PDF-file.

> Simon A, Van der Meer JWM, Veselý R, Myrdal U, Yoshimura K, Duys P, Drenth JPH & contributing members of the International HIDS Study Group. Approach to genetic analysis in diagnosis of hereditary autoinflammatory syndromes. Rheumatology, published online; doi:10.1093/rheumatology/kei138.

> Simon A, Van der Meer JWM, Drenth JPH. Familial Mediterranean Fever – a not so unusual cause of abdominal pain. Best Practice and Research in Clinical Gastroenterology 2005; 19:199-213. PDF-file.

> Van der Hilst JCH, Simon A, Drenth JPH. Hereditary Periodic fever and reactive amyloidosis. Clin Exp Med 2005; 5:87-98.

> Lipsker D, Imrie K, Simon A, Sullivan KE. Hot and hobbling with hives: Schnitzler syndrome. Clin Immunology 2005, published online dec 19.

 

Events

> In December 2005, Anna Simon was awarded a research grant from the Netherlands Organization for Scientific Research (NWO, VENI).

> Anna Simon won the Young Investigator Award at the Fourth International Conference on Systemic Autoinflammatory Diseases in Bethesda.

> Both Jeroen van der Hilst and Heleen de Koning were awarded a travel stipend for the fourth International Conference on Systemic Autoinflammatory Diseases in Bethesda.

> PhD thesis Anna Simon nominated for the Dr. C.J. Roosprize, for best thesis on clinical research in the area of Internal Medicine in the Netherlands in 2004. Oral presentation of thesis and prize ceremony during Internistendagen, April 21-22, 2005.

Publications

> Simon A, Kremer HPH, Wevers RA, Scheffer H, de Jong JG, van der Meer JWM, Drenth JPH. Mevalonate kinase deficiency: evidence for a phenotypic continuum. Neurology 2004; 62:994-7. PDF file.

> Bodar EJ, Simon A, van der Hilst JCH, van Deuren M. Two patients with recurrent fever and wine red discolouration of the eyelids. Photoquiz. Neth J Med 2004; 62:119,139. PDF file—answer.

> Simon A, Drewe E, van der Meer JWM, Powell RJ, Kelley RI, Stalenhoef AFH, Drenth JPH.  Simvastatin treatment for inflammatory attacks of the hyper-IgD and periodic fever syndrome. Clin Pharm Therap 2004; 75: 476-83. PDF file.

> Simon A, Bijzet J, Voorbij HAM, Mantovani A, Van der Meer JWM, Drenth JPH. Effect of inflammatory attacks in the classical type hyper-IgD syndrome on immunoglobulin D, cholesterol and parameters of the acute phase response. J Intern Med 2004; 256:247-53. PDF file.

> Simon A, Bodar EJ, Fiselier TJW, Cuppen MPJM, Van der Hilst JCH, Drenth JPH, van der Meer JWM. Beneficial response to interleukin-1-receptor antagonist in a patient with severe, treatment-resistant TNF-receptor associated periodic syndrome (TRAPS). Am J Med 2004; 117:208-10. PDF file.

> Simon A, Van der Meer JWM, Drenth JPH. Familial auto-inflammatory syndromes. Kelley’s Textbook of Rheumatology, 2004, chapter 112.

 

Events

> November 4: PhD ceremony Anna Simon (cum laude)

> November 4: symposium on Twenty years HIDS 1984-2004 at the Radboud University Nijmegen, the Netherlands

Publications

> Simon A, Mariman EC, Van der Meer JWM, Drenth JPH. Major mutation of the hyper-IgD and periodic fever syndrome originates from one common ancestor – truly Dutch type periodic fever? Am J Med 2003; 114:148-52. PDF file.

> Van der Hilst JC, Simon A, Drenth JP. Molecular mechanisms of amyloidosis. N Engl J Med. 2003; 349:1872-3 (letter). PDF file.

 

Events

> September: Jeroen van der Hilst and Evelien Bodar joined our research team as PhD students, in a combined specialist training and PhD program.

> August: Heleen de Koning, a second year medical student, joins our team to start up research on Schnitzler syndrome—an acquired periodic fever syndrome.

Publications

Events